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By Abelson J.N., Simon M.I., Phillips I.M.

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Treatment of rats with an intrahippocampal infusion of antisense ODN to the GABAA receptor 72 subunit decreases benzodiazepine receptor binding. [3H]Flunitrazepam binding to hippocampal membrane preparations after continuous intrahippocampal infusion of antisense or mismatch control ODN for 5 days. MM4 is a mismatch ODN with the four central bases of the antisense ODN interchanged; in MM2 the two central bases are interchanged (see Table I). ; n = 9). 01 versus untreated control, MM4, or MM2 (Mann-Whitney U test).

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