By Wieslaw M. Kazmierski
This ebook makes a speciality of new small molecule methods to wrestle viral infections. The chapters describe the invention and improvement from bench in the course of the sanatorium of quite recently-approved antiviral medicinal drugs and compounds in complicated medical improvement. geared up through an epidemic (such as HIV, HCV, RSV, influenza, HBV and CMV) and written through best educational and commercial professionals within the box, the e-book presents a different chance to review, comprehend and observe discovery and improvement rules and studying with no the necessity for anyone to analyze, study and synthesize all enormous sourcing references. themes show off demanding situations and strategies of matters encountered, offering tremendous adventure amassed over a long time of analysis that might be really priceless to easy and bench scientists in addition to clinicians as they proceed getting to know and constructing new medicines and remedies.
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Extra info for Antiviral Drugs: From Basic Discovery Through Clinical Trials
In the study of fertility and reproductive performance in rats (100, 375, and 1400 mg/kg per day), drug-related effects were limited to prolonged diestrus with abbreviated estrus and metestrus in females at all doses. Minimally lower fertility was seen in female rats at 1400 mg/kg per day; however, fertility was only marginally below that observed historically in control rats. This finding was not duplicated in a second fertility study at 1400 mg/kg per day; and therefore, the reduced fertility was considered not to be drug related.
The results of the genotoxicity, carcinogenicity, and investigative studies support the fact that atazanavir is not a genotoxic carcinogen and does not pose a carcinogenic risk to humans. Therefore, there were no nonclinical findings that precluded the safe administration of atazanavir for treatment of HIV infection in humans. MICROBIOLOGY AND RESISTANCE Atazanavir exhibits anti-HIV-1 activity with a mean 50% effective concentration (EC50 ) in the absence of human serum of 2 to 5 nM against a variety of laboratory and clinical HIV-1 isolates grown in peripheral blood mononuclear cells, macrophages, CEM-SS cells, and MT-2 cells.
Comparison of once daily atazanavir with efavirenz, each in combination with fixeddose zidovudine and lamivudine, as initial therapy for patients infected with HIV. J. Acquir. Immune Defic. Syndr. 2004, 36, 1011–1019. ; Fessel, W. ; McLaren, C. Comparison of atazanavir with lopinavir/ritonavir in patients with prior protease inhibitor failure: a randomized multinational trial. Curr. Med. Res. Opin. 2005, 10, 1683–1692. Malan, D. ; McGrath, D. Efficacy and safety of atazanavir, with or without ritonavir, as part of once-daily highly active antiretroviral therapy regimens in antiretroviral-naive patients.