Download Chemokine Biology — Basic Research and Clinical Application: by Marco Baggiolini (auth.), Bernhard Moser, Gordon L. Letts, PDF

By Marco Baggiolini (auth.), Bernhard Moser, Gordon L. Letts, Kuldeep Neote (eds.)

The discovery of interleukin-8 with reference to two decades in the past initiated a brand new box of study pertaining to many facets of immunology and irritation. Interleukin-8 is only one member of a big category of structurally similar chemoattractant proteins, referred to as chemokines. Chemokines are interested in the site visitors keep watch over of leukocytes, which endure the corresponding chemokine receptors on their surfaces. at the present time, it really is transparent that chemokines impact all elements of immunology or even many unrelated fields, resembling tissue improvement and tumor cellphone metastasis. Their basic contributions to persistent inflammatory ailments cause them to a crucial aim for the improvement of novel, anti inflammatory therapeutics.

This set of books* supplies a state of the art account of contemporary advancements during this box within the type of summaries written through very popular specialists. quantity I is targeted on easy ideas and development in chemokine biology, and quantity II offers with concerns regarding chemokine-related drug improvement and capability healing functions. those volumes offer either introductory and novel info for a wide readership, together with clinicians and biomedical scientists.

*See additionally ok. Neote/G.L. Letts/B. Moser, Chemokine Biology - simple examine and medical software. quantity II: Pathophysiology of Chemokines. 2006, Birkhäuser, growth in irritation examine, ISBN 3-7643-7195-1.

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Additional info for Chemokine Biology — Basic Research and Clinical Application: Volume I: Immunobiology of Chemokines

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J Leukoc Biol 72: 1–8 Banchereau J, Briere F, Caux C, Davoust J, Lebecque S, Liu YJ, Pulendran B, Palucka K (2000) Immunobiology of dendritic cells. Annu Rev Immunol 18: 767–811 Steinman RM, Hawiger D, Nussenzweig MC (2003) Tolerogenic dendritic cells. Annu Rev Immunol 21: 685–711 Schaerli P, Ebert L, Willimann K, Blaser A, Roos RS, Loetscher P, Moser B (2004) A 29 Charles R. Mackay and Bernhard Moser 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 Skin-selective homing mechanism for human immune surveillance T cells.

In terms of functional criteria, the order in relatedness of the main subsets would be naïve T cells, TCM cells, TEM cells and effector T cells, although alternative models in the sequence of T cell differentiation have also been proposed. Still, naïve T cells share many functional and homing features with TCM cells whereas effector T cells share many characteristics with TEM cells. Tissue-selectivity of memory T cells Tissue-specific migration by T cells was first observed in the 1970s in sheep and then in mice.

Hence, the understanding of mechanisms mediating memory T cell recruitment to the skin may identify promising targets for the development of novel therapeutics. Atopic dermatitis Atopic dermatitis is a chronic or chronically relapsing inflammatory skin disease with eczematous lesions demonstrating typical morphology and distribution, severe pruritus, elevated serum IgE, the presence of allergen-specific IgE, and peripheral blood eosinophilia [74]. The prevalence of atopic dermatitis rapidly increased during the past decades and is currently ranging between 10–20% in children and 1–3% in adults.

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